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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: Jul 2, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Skin biopsy as a diagnostic tool.

Claudia Sommer1

  • 1Department of Neurology, University of Würzburg, Germany. sommer@uni-wuerzburg.de

Current Opinion in Neurology
|September 5, 2008
PubMed
Summary

Skin biopsy is a valuable tool for diagnosing neuropathies, especially small fiber neuropathy. New data confirm its effectiveness and highlight its role in identifying treatable conditions and understanding disease mechanisms.

Area of Science:

  • Neurology
  • Pathophysiology
  • Diagnostic Medicine

Background:

  • Neuropathies encompass a range of disorders affecting nerve function.
  • Small fiber neuropathy (SFN) diagnosis can be challenging.
  • Skin biopsy offers a minimally invasive approach to assess nerve involvement.

Purpose of the Study:

  • To review recent advancements in using skin biopsy for neuropathy diagnosis.
  • To highlight the diagnostic and research utility of skin biopsy.
  • To explore novel applications and emerging methodologies.

Main Methods:

  • Review of current literature on skin biopsy in neuropathy.
  • Analysis of diagnostic accuracy (sensitivity and specificity) for SFN.
  • Integration of histological findings with in-vivo microscopy and neurophysiology.

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Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
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Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay

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Main Results:

  • New data support the high sensitivity and specificity of skin biopsy for SFN.
  • Skin biopsy aids in identifying treatable causes of SFN.
  • Innervation changes are observed in conditions previously thought to affect only large fibers.
  • Novel methods enhance histological evaluation of skin innervation.
  • Skin biopsy contributes to understanding neuropathy pathophysiology (e.g., VEGF in diabetic neuropathy, cytokines in painful SFN).
  • Quantification of skin innervation serves as a clinical trial outcome measure.

Conclusions:

  • Skin biopsy is evolving from a descriptive tool to one aiding etiological diagnosis.
  • It is valuable for clinical trial follow-up and pathophysiological research in neuropathies.
  • Its role in comprehensive neuropathy workup is increasingly recognized.