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Related Experiment Videos

Significant cost-saving with modification of antihypertensive therapy.

G R Keeton1, M T Monteagudo

  • 1Department of Medicine, University of Cape Town.

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|August 17, 1991
PubMed
Summary

Switching from nifedipine to reserpine and thiazide improved blood pressure control and significantly reduced treatment costs for hypertension patients. This alternative therapy demonstrated a 73% cost saving per patient over six months.

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Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Nifedipine is commonly prescribed for hypertension and chest pain.
  • Concerns exist regarding nifedipine's side-effect profile and cost.
  • Alternative antihypertensive regimens require evaluation for efficacy and cost-effectiveness.

Purpose of the Study:

  • To assess the efficacy and safety of an alternative antihypertensive regimen.
  • To evaluate the cost reduction associated with the new treatment plan.
  • To determine the impact of switching from nifedipine to reserpine and thiazide.

Main Methods:

  • A 6-month follow-up study of 30 patients at Somerset Hospital Outpatient Department.
  • Patients previously treated with nifedipine were switched to a new regimen.

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  • The new regimen primarily included reserpine combined with a thiazide.

    • Main Results:

    • Improved blood pressure control was observed after the treatment change.
    • No serious side-effects were reported during the follow-up period.
    • The monthly cost per patient decreased by 73%, from R54 to R14.

    Conclusions:

    • Alternative antihypertensive therapy using reserpine and thiazide is effective and well-tolerated.
    • Significant cost savings can be achieved by optimizing antihypertensive drug choices.
    • A more considered approach to selecting antihypertensive agents is recommended, with careful attention to dosage, particularly for reserpine (max 0.1 mg/day).