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Olfactory Assays for Mouse Models of Neurodegenerative Disease
Published on: August 25, 2014
Neuroleptic-induced parkinsonism is associated with olfactory dysfunction.
Stephanie Krüger1, Antje Haehner, Claudia Thiem
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany.
Journal of Neurology
|September 5, 2008
Summary
Drug-induced extrapyramidal symptoms (EPS) in depressed patients are linked to olfactory deficits. Olfactory function declines with increased EPS severity, suggesting a drug-induced cause in affective disorders.
Area of Science:
- Neuroscience
- Psychiatry
- Otolaryngology
Background:
- Olfactory deficits are noted in extrapyramidal disorders.
- Limited data exists on olfactory function in drug-induced extrapyramidal symptoms (EPS).
Purpose of the Study:
- Investigate olfactory function in depressed patients with drug-induced parkinsonism (EPS).
- Compare olfactory function between depressed patients with EPS, without EPS, and neuroleptic-naive controls.
Main Methods:
- Included 79 depressed patients: 15 with EPS, others without EPS, and neuroleptic-naive controls.
- Utilized "Sniffin' Sticks" for psychophysical olfactory testing (odor thresholds, identification, discrimination).
Main Results:
- EPS group showed significantly lower olfactory scores than no-EPS and no-NL groups.
- Olfactory function correlated negatively with EPS severity (odor thresholds, identification).
Conclusions:
- Olfactory deficits may be drug-induced in primary affective disorder patients prone to EPS.
- Suggests a link between neuroleptic treatment, EPS development, and olfactory impairment.
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