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Updated: Jul 2, 2026
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Induction and Monitoring of Active Delayed Type Hypersensitivity (DTH) in Rats
Published on: July 19, 2007
Delayed hypersensitivity in the fowl, turkey and quail
1Houghton Poultry Research Station, Houghton Huntingdon, Cambs., England.
Avian Pathology : Journal of the W.V.P.A
|January 1, 1977
Summary
This study shows that chickens, turkeys, and quail exhibit delayed hypersensitivity reactions to intradermal antigens. While reactions were histologically similar across species, quail showed lower macroscopic reactivity, especially in non-anal sites.
Area of Science:
- Immunology
- Veterinary Pathology
- Comparative Medicine
Background:
- Delayed hypersensitivity is a key immune response.
- Understanding avian immune responses is crucial for poultry health and disease research.
- Previous studies have characterized delayed hypersensitivity in mammals, but avian models require further investigation.
Purpose of the Study:
- To investigate and compare delayed hypersensitivity reactions in chickens, turkeys, and quail.
- To evaluate different injection sites for eliciting these immune responses.
- To provide histological and gross pathological descriptions of avian delayed hypersensitivity.
Main Methods:
- Sensitized fowls (chickens, turkeys, quail) received intradermal injections of antigens.
- Reactions were assessed macroscopically and microscopically (histologically).
- Various anatomical sites were used for antigen administration.
Main Results:
- All tested avian species demonstrated delayed hypersensitivity.
- Histological findings were consistent across chickens, turkeys, and quail.
- Turkeys and quail showed reduced reactivity compared to chickens, with quail reactions often only detectable macroscopically at the anal site.
- Gross reactions differed from guinea pigs and rabbits but aligned with rat and mouse responses.
Conclusions:
- Chickens, turkeys, and quail are suitable models for studying delayed hypersensitivity.
- Site selection impacts the macroscopic detection of avian delayed hypersensitivity.
- Comparative analysis reveals species-specific differences in the intensity of delayed hypersensitivity reactions in birds.
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