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Is hsp70 the cellular thermometer?

E A Craig¹, C A Gross

¹Department of Physiological Chemistry, University of Wisconsin-Madison 53706.

Trends in Biochemical Sciences

|April 1, 1991

Abstract:

Cells respond to an increase in temperature by inducing the synthesis of the heat shock proteins, which are a small set of evolutionarily conserved proteins. We review the evidence leading us to suggest that the free pool of one of these proteins, hsp70, serves as a cellular thermometer that regulates the expression of all heat shock proteins.

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