New constituents of Artemisia monosperma Del

Phytochemical investigation of air-dried powdered roots of Artemisia monosperma growing in Egypt afforded two new compounds; 6-hydroxy-7,8-dimethoxycoumarin (I) and 5-acetyl-2-[1'-(hydroxymethyl)ethyl]-2,3-dihydrobenzo[b]furan (IV), in addition to the known compounds; 6-hydroxy-5,7-dimethoxycoumarin (fraxinol) (II), 5-hydroxy-6,7-dimethoxycoumarin (tomentin) (III) and methyl-beta-D-fructofuranoside (V), obtained for the first time from the plant. Chemical structures of the isolated compounds were assigned based on different physical, chemical and spectroscopic techniques including UV, IR, MS, 1D- and 2D-NMR spectra. Furthermore, antimicrobial activity of different extracts of roots was carried out.