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Updated: Jul 2, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Clinical, histologic, and histomorphometric analyses of regenerated bone in maxillary sinus augmentation using fresh
Claudio Stacchi1, Giovanna Orsini, Donato Di Iorio
1Department of Biomedicine, University of Trieste, Trieste, Italy.
Background:
The purpose of the present study was the clinical and the histologic evaluation of fresh frozen human bone (FFB) allografts used for maxillary sinus-augmentation procedures.
Methods:
Ten subjects were treated with maxillary sinus augmentations using FFB. Radiologic measurements were recorded on computed tomography scans preoperatively and 5 months after the sinus surgeries. At 5 months, during implant placement, 10 core biopsies were retrieved and processed for histomorphometric evaluation under light microscopy (LM). Clinical and histomorphometric measurements are presented as mean +/- SD.
Results:
At baseline, the height of the alveolar ridge measured 4.3 +/- 1.3 mm (mean); after augmentation procedures, at implant positioning, it had a mean height of 16.0 +/- 1.8 mm. All 22 dental implants were clinically healthy after 5 months. LM showed that most of the specimens presented newly formed bone that was completely integrated with preexisting bone. The interface areas between new and old bone were not discernible. Woven bone was present in some areas of the biopsies; however, in the majority of the examined regions, there was mature osseous tissue presenting features of trabecular bone. There was no evidence of an acute inflammatory infiltrate. Histomorphometry revealed that the percentage of bone was 48.15% +/- 14.32%, whereas marrow spaces occupied the rest of the area.
Conclusion:
FFB is a biocompatible material that can be successfully used for maxillary sinus augmentations without interfering with normal reparative bone processes.
