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Updated: Jul 2, 2026
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
The disappearing act of factor VIII
P J Lenting1, O D Christophe, P Guéguen
1Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry & Haematology, University Medical Center Utrecht, Utrecht, The Netherlands. peter.lenting@crucell.com
Haemophilia : the Official Journal of the World Federation of Hemophilia
|September 6, 2008
Summary
Factor VIII (FVIII) is crucial for blood clotting and linked to bleeding and clotting disorders. Research explores how FVIII interacts with surface receptors, impacting its function and survival.
Area of Science:
- Hematology
- Biochemistry
- Molecular Biology
Background:
- Factor VIII (FVIII) is a vital plasma protein in hemostasis.
- Its absence causes hemophilia A, a severe bleeding disorder.
- Elevated FVIII levels are linked to thrombotic complications.
Purpose of the Study:
- To review the interactions between FVIII and surface receptors.
- To understand how these interactions influence FVIII function and survival.
Main Methods:
- Literature review of studies on FVIII and its interactions.
- Analysis of research on FVIII structure, function, and physiology.
Main Results:
- FVIII interactions with surface receptors are critical.
- These interactions can modulate FVIII's biological activity.
- Surface receptor binding may affect FVIII's lifespan in circulation.
Conclusions:
- Understanding FVIII-receptor interactions is key to comprehending hemostatic defects.
- This knowledge may offer insights into managing bleeding and thrombotic disorders.
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