Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
Veins as Blood Reservoirs01:10

Veins as Blood Reservoirs

Veins, while chiefly responsible for circulating blood back to the heart, also function as storage vessels for blood. They house approximately 64 percent of the body's total blood volume, a feat made possible by their high capacitance—the inherent ability to expand and accommodate large volumes of blood, even under low pressure. The large diameter and thin walls of veins augment their distensibility, significantly more so than arteries, due to their classification as capacitance vessels. When...
Measurement of Blood Pressure01:17

Measurement of Blood Pressure

Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a stethoscope.
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of night shift work on vascular function in healthy adult workers.

Journal of hypertension·2026
Same author

Emergency Laparoscopic Cholecystectomy for Acute Cholecystitis with Hepatic Segment 4 Hypoplasia and Gallbladder-Attached Accessory Liver: A Rare Dual Anomaly Case.

Surgical case reports·2026
Same author

Valacyclovir-Induced Encephalopathy in a Frail Oldest-Old Resident of a Geriatric Health Services Facility: Implications for Safety-First Antiviral Dosing.

Geriatrics & gerontology international·2026
Same author

IgG4-Related Kidney Disease With Hypocomplementemia and Circulating Immune Complex Containing IgG3 Presenting as Rapidly Progressive Glomerulonephritis: A Case Report.

Kidney medicine·2026
Same author

Association of anti SITH 1 antibody titer with mental stress and intracranial aneurysms.

Scientific reports·2026
Same author

Efficacy and Safety of Stent-Assisted Coiling with Low-Profile Visualized Intraluminal Support versus Neuroform Atlas for Unruptured Internal Carotid Aneurysms: A Propensity Score-Matched Analysis.

AJNR. American journal of neuroradiology·2026

Related Experiment Video

Updated: Jul 2, 2026

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
09:56

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

Bell-shaped relationship between central blood volume and spontaneous baroreflex function.

Takashi Saitoh1, Yojiro Ogawa, Ken Aoki

  • 1Department of Social Medicine, Division of Hygiene, Nihon University School of Medicine, Tokyo 173-8610, Japan.

Autonomic Neuroscience : Basic & Clinical
|September 6, 2008
PubMed
Summary

Spontaneous baroreflex function changes with central blood volume. The study found this relationship is bell-shaped, with optimal function at moderate hypervolemia, not extreme levels.

More Related Videos

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
11:26

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Published on: December 10, 2014

Software for Analysis of Heart Rate and Blood Pressure Time-series Data from the Valsalva Maneuver
14:28

Software for Analysis of Heart Rate and Blood Pressure Time-series Data from the Valsalva Maneuver

Published on: June 27, 2025

Related Experiment Videos

Last Updated: Jul 2, 2026

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
09:56

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
11:26

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Published on: December 10, 2014

Software for Analysis of Heart Rate and Blood Pressure Time-series Data from the Valsalva Maneuver
14:28

Software for Analysis of Heart Rate and Blood Pressure Time-series Data from the Valsalva Maneuver

Published on: June 27, 2025

Area of Science:

  • Physiology
  • Cardiovascular Regulation

Background:

  • Spontaneous baroreflex function is crucial for maintaining blood pressure homeostasis.
  • Acute changes in central blood volume are known to affect baroreflex sensitivity.
  • Previous research suggested a dose-effect relationship, but it remained unquantified across a wide range of central blood volumes.

Purpose of the Study:

  • To quantify the relationship between central blood volume and spontaneous baroreflex function.
  • To investigate the effects of stepwise hypovolemia and hypervolemia on baroreflex sensitivity.
  • To determine the optimal level of central blood volume for maximal spontaneous baroreflex function.

Main Methods:

  • Twelve healthy individuals participated in the study.
  • Central hypovolemia was induced using lower body negative pressure (LBNP) at -15 and -30 mm Hg.
  • Hypervolemia was achieved through normal saline infusions of 15 ml/kg and 30 ml/kg.
  • Spontaneous baroreflex function was assessed using transfer function analysis and the sequence method, analyzing blood pressure and R-R interval data.

Main Results:

  • Both central venous pressure and left ventricular end-diastolic volume changed predictably with LBNP and saline infusions.
  • Spontaneous baroreflex indices, including high-frequency transfer function gain and sequence slope, increased with moderate hypervolemia (NS15).
  • However, baroreflex function decreased at higher hypervolemia (NS30) and was lowest during severe hypovolemia (LBNP30).

Conclusions:

  • The relationship between central blood volume and spontaneous baroreflex function follows a bell-shaped curve.
  • Maximal augmentation of spontaneous baroreflex function occurs at moderate levels of hypervolemia.
  • Extreme hypovolemia or hypervolemia impairs spontaneous baroreflex function, highlighting the importance of optimized central blood volume for cardiovascular regulation.