Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Affecting Neurotransmitter Release or Uptake01:21

Drugs Affecting Neurotransmitter Release or Uptake

1.5K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.5K
Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

3.3K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
3.3K
Electrical Synapses01:28

Electrical Synapses

10.0K
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
10.0K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

2.0K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.0K
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

12.3K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
12.3K
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

710
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
710

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Baseline Computed Tomography Coronary Angiography and Polygenic Risk Profiles in Adults With Type 2 Diabetes: A Cross-Sectional Analysis From the VOLTAIRE Study.

Diabetes, obesity & metabolism·2026
Same author

Time as the language of behavior: Events, sequences, patterns and meanings.

Journal of neuroscience methods·2026
Same author

Thalamic 5-HT<sub>2A</sub> receptor activation reduces GABA uptake, increases tonic GABA<sub>A</sub> inhibition and induces absence seizures in Wistar rats.

Neuropharmacology·2026
Same author

Evaluation of Polygenic Scores and CT Imaging in Risk Factor Modification in Patients With Diabetes: Rationale and Design of the VOLTAIRE Study.

Clinical cardiology·2026
Same author

Debridement, Antibiotics and Implant Retention in the Management of Periprosthetic Joint Infection: One-Year Outcomes, Epidemiology and Predictors of Failure.

Journal of clinical medicine·2026
Same author

Syndecan-1, endocan and non-culprit coronary plaque composition following non-ST elevation myocardial infarction.

International journal of cardiology. Heart & vasculature·2026

Related Experiment Videos

Serotonin-dopamine interaction: electrophysiological evidence.

Giuseppe Di Giovanni1, Vincenzo Di Matteo, Massimo Pierucci

  • 1Dipartimento di Medicina Sperimentale, Sezione di Fisiologia Umana G. Pagano, Università di Palermo, Corso Tuköry 129, 90134 Palermo, Italy.

Progress in Brain Research
|September 6, 2008
PubMed
Summary

Serotonin (5-hydroxytryptamine, 5-HT) and dopamine (DA) pathways in the brain interact reciprocally. Electrophysiological studies reveal complex, often inhibitory, 5-HT modulation of DA neuron activity, impacting neuropsychiatric disorders.

Related Experiment Videos

Area of Science:

  • Neuroscience
  • Neuropharmacology

Background:

  • The brain's serotonin (5-hydroxytryptamine, 5-HT) and dopamine (DA) systems are crucial for regulating mood, cognition, and motor control.
  • Dysregulation in 5-HT/DA balance is implicated in various neuropsychiatric disorders.

Purpose of the Study:

  • To review and discuss the intricate interactions between central 5-HT and DA systems.
  • To elucidate the electrophysiological mechanisms underlying 5-HT modulation of DA neuron activity.

Main Methods:

  • In vivo and in vitro electrophysiological recordings.
  • Neuroanatomical tracing techniques.
  • Analysis of receptor subtype-specific effects.

Main Results:

  • DA neurons receive significant innervation from 5-HT raphe nuclei, with reciprocal innervation from DA to 5-HT neurons.
  • 5-HT exerts complex, predominantly inhibitory, effects on midbrain DA neurons (VTA and SNc) via various receptor subtypes.
  • 5-HT modulates DA neuron activity both directly and indirectly through GABAergic and glutamatergic pathways.

Conclusions:

  • The 5-HT/DA interaction is complex, involving direct and indirect modulatory mechanisms.
  • Further research using selective receptor ligands is essential for a comprehensive understanding and for developing novel therapeutic strategies for neuropsychiatric conditions.