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Related Experiment Video

Updated: Jul 2, 2026

Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis

Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis

Published on: June 13, 2021

Candida albicans cell wall proteins.

W LaJean Chaffin¹

¹Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, 3601 4th St., Lubbock, TX 79430, USA. LaJean.Chaffin@ttuhsc.edu

Microbiology and Molecular Biology Reviews : MMBR

|September 6, 2008

Summary

This review details the three classes of proteins in the Candida albicans cell wall, exploring their attachment, secretion, and function. Understanding these fungal cell wall proteins is crucial for antifungal research.

Area of Science:

Mycology
Cell Biology
Biochemistry

Background:

The Candida albicans cell wall is essential for structural integrity and environmental interaction.
Major cell wall components include fibrillar polysaccharides and proteins.

Purpose of the Study:

This review focuses on the diverse classes of proteins within the Candida albicans cell wall.
It aims to discuss their identification, function, and regulation.

Main Methods:

Genome sequence analysis to predict protein constituents.
Experimental validation to identify protein classes and members.
Analysis of protein function, mutant phenotypes, and regulatory mechanisms.

Main Results:

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Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis

Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis

Published on: June 13, 2021

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Three distinct classes of cell wall-associated proteins in Candida albicans have been identified.

Proteins are categorized by their attachment mechanisms: GPI anchors/alkali-labile linkages, classical secretory pathways, or unknown surface association pathways.

Members from all three classes have been experimentally confirmed.

Conclusions:

The review provides a detailed examination of specific cell wall proteins, their functions, and regulatory controls.
Understanding these proteins is vital for targeting Candida albicans in therapeutic strategies.