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Updated: Jul 2, 2026
Construction of An Orthotopic Xenograft Model of Non-Small Cell Lung Cancer Mimicking Disease Progression and Predicting Drug Activities
Published on: May 10, 2024
[Construction of 2-dimensional tumor microvascular architecture phenotype in non-small cell lung cancer]
Jin-kang Liu1, Xiao-yi Wang, Zeng Xiong
1Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.
Objective:
To construct a technological platform of 2-dimensional tumor microvascular architecture phenotype (2D-TAMP) expression.
Methods:
Thirty samples of non-small cell lung cancer (NSCLC) were collected after surgery. The corresponding sections of tumor tissue specimens to the slice of CT perfusion imaging were selected. Immunohistochemical staining,Gomori methenamine silver stain, and electron microscope observation were performed to build a technological platform of 2D-TMAP expression by detecting the morphology and the integrity of basement membrane of microvasculature, microvascular density, various microvascular subtype, the degree of the maturity and lumenization of microvasculature, and the characteristics of immunogenetics of microvasculature.
Results:
The technological platform of 2D-TMAP expression was constructed successfully. There was heterogeneity in 2D-TMAP expression of non-small cell lung cancer. The microvascular of NSCLC had certain characteristics.
Conclusion:
2D-TMAP is a key technology that can be used to observe the overall state of micro-environment in tumor growth.
