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Updated: Jul 2, 2026
A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse
Published on: December 16, 2022
[Systematic continuous sequence approach in diagnosing fetal deformity]
Qi-neng Chen1, Wei-she Zhang, Jin-xiu Tan
1Department of Gynecology and Obstetrics, Xiangya Hospital, Central South University, Changsha 410008, China.
Objective:
To explore the value of ultrasonographic evaluation in fetal deformity in prenatal diagnosis by a systematic continuous sequence approach (SCSA).
Methods:
Successive prenatal ultrasonographic evaluation was performed to monitor the whole anatomic structure,form, posture and movement of 16,685 fetuses during gestation aging 14 approximately 40(+3) weeks.
Results:
Satisfactory ultrasonic images were obtained in 16,627 fetuses using the SCSA (99.65%). Of them, 514 abnormal fetuses were confirmed after subsequent labor or induced labor and 498 abnormal fetuses were correctly diagnosed using SCSA during prenatal stage (96.89%). Whereas 16 fetuses missed recognition (3.11%). Its sensitivity, specificity, positive and negative predictive value of diagnosis on fetal deformity were 96.98%, 99.96%, 98.66%, and 99.90 %, respectively.
Conclusion:
SCSA in prenatal ultrasonographic evaluation of the fetal structure and malformation is reliable and accurate.
