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Related Experiment Video

Updated: Jul 2, 2026

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

Cardiac regenerative medicine.

Shinsuke Yuasa¹, Keiichi Fukuda

¹Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan.

Circulation Journal : Official Journal of the Japanese Circulation Society

|September 6, 2008

Summary

Regenerative cardiac medicine offers hope for severe heart failure. Induced pluripotent stem cells (iPS cells) derived from fibroblasts show promise as an ideal, autologous cell source for repairing heart muscle damage.

Area of Science:

Cardiovascular Research
Stem Cell Biology
Regenerative Medicine

Background:

Severe heart failure involves irreversible myocardial damage.
Current therapies are insufficient for myocardial repair.
Regenerative medicine offers potential solutions for cardiac repair.

Purpose of the Study:

To explore potential cell sources for regenerative cardiac medicine.
To evaluate induced pluripotent stem (iPS) cells as a viable option.
To highlight the integration of diverse scientific fields for cardiac regeneration.

Main Methods:

Review of experimental and clinical studies on cardiac regenerative medicine.
Establishment of induced pluripotent stem (iPS) cells from fibroblasts via transcription factor gene transfer (Oct3/4, Sox2, Klf4, c-Myc).

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Last Updated: Jul 2, 2026

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing

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Published on: March 19, 2013

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

Assessment of iPS cell differentiation potential and syngeneic properties.

Main Results:

Embryonic stem (ES) cells are proliferative but not autologous and lack selective cardiomyocyte induction protocols.
iPS cells can be generated from fibroblasts and differentiate into all three germ layers.
iPS cells are syngeneic, making them a promising autologous cell source.

Conclusions:

Induced pluripotent stem cells represent an ideal cell source for regenerative cardiac medicine.
Further integration of developmental biology, stem cell biology, and tissue engineering is crucial.
Achieving the full potential of cardiac regenerative medicine requires a multidisciplinary approach.