Pediatric ophthalmology in the developing world

Jennifer M Maida1, Keith Mathers, Cynthia L Alley

  • 1Department of Ophthalmology, Temple University, Philadelphia, Pennsylvania 19140, USA.

Insights

Childhood blindness in developing nations is a major issue. Progress in treating conditions like vitamin A deficiency, congenital cataracts, and retinopathy of prematurity offers hope for improved vision outcomes.

Area of Science:

  • Ophthalmology
  • Public Health
  • Global Health

Background:

  • Childhood blindness affects 1.4 million children in low- and middle-income countries, primarily in Africa and Asia.
  • Key causes include vitamin A deficiency, congenital cataracts, and retinopathy of prematurity.
  • Uncorrected refractive errors also contribute significantly to visual impairment.

Purpose of the Study:

  • To review the status of pediatric ophthalmology in developing countries.
  • To discuss progress in managing avoidable childhood blindness and visual impairment.
  • To examine the prevalence of uncorrected refractive errors and access to pediatric ophthalmologists.

Main Methods:

  • Review of existing literature and public health initiatives.
  • Analysis of trends in childhood blindness causes.
  • Assessment of healthcare access and interventions in developing nations.

Main Results:

  • Vitamin A supplementation and measles immunization have reduced xerophthalmia in some regions.
  • Cataracts are an increasingly apparent cause of treatable childhood blindness.
  • Amblyopia and refractive errors, particularly myopia, are common and treatable.
  • Retinopathy of prematurity is emerging as a significant cause of blindness due to improved neonatal care.

Conclusions:

  • Childhood blindness and visual impairment remain critical public health challenges in developing countries.
  • Ongoing initiatives demonstrate potential for future improvements in pediatric eye care.
  • Addressing avoidable causes and improving access to specialists are crucial for progress.
Abstract

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...