Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemical peritonitis associated with intraperitoneal vancomycin.

T A Smith1, G R Bailie, G Eisele

  • 1Albany College of Medicine, Union University, NY.

DICP : the Annals of Pharmacotherapy
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An experimental study of underwater radiated noise from a small vessel with damaged and fouled propellers.

JASA express letters·2024
Same author

Increased paediatric presentations of severe diabetic ketoacidosis in an Australian tertiary centre during the COVID-19 pandemic.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

Nanomorphology of polythiophene-fullerene bulk-heterojunction films investigated by structured illumination optical imaging and time-resolved confocal microscopy.

Methods and applications in fluorescence·2017
Same author

Sportsmedicine forum.

The Physician and sportsmedicine·2016
Same author

The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015.

Nature·2015
Same author

Impulse control disorders in Parkinson's disease: don't set your mind at rest by self-assessments.

European journal of neurology·2015

A patient developed chemical peritonitis after receiving intraperitoneal vancomycin for a dialysis catheter infection. Symptoms resolved after discontinuing the antibiotic, suggesting a drug-induced reaction.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pharmacology

Background:

  • Peritonitis is a serious complication for patients undergoing chronic ambulatory peritoneal dialysis (CAPD).
  • Vancomycin is commonly used to treat bacterial infections in CAPD patients, particularly exit-site infections.

Observation:

  • A 23-year-old female CAPD patient presented with a catheter exit-site infection.
  • Intraperitoneal vancomycin was administered, leading to the development of abdominal pain and cloudy dialysate within days.
  • These symptoms resolved after vancomycin discontinuation, with negative fluid cultures.

Findings:

  • The clinical presentation, negative cultures, and rapid resolution upon vancomycin cessation strongly indicate vancomycin-induced chemical peritonitis.
  • Subsequent administration of lower-dose intraperitoneal vancomycin did not reproduce the symptoms.

Related Experiment Videos

  • Laboratory tests including white blood cell counts, immunoglobulins, and complement levels supported the diagnosis.

    • Implications:

    • This case highlights the potential for vancomycin to cause chemical peritonitis in CAPD patients.
    • Clinicians should consider drug-induced peritonitis when evaluating new-onset abdominal symptoms in CAPD patients receiving intraperitoneal antibiotics.
    • Careful dosing and monitoring of intraperitoneal vancomycin may be necessary to prevent adverse events.