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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

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Related Experiment Video

Updated: Jul 2, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

Can genes for mammographic density inform cancer aetiology?

Linda E Kelemen1, Thomas A Sellers, Celine M Vachon

  • 1Department of Population Health Research, Alberta Cancer Board, 1,331 29th Street North West, Calgary, Alberta T2N 4N2, Canada.

Nature Reviews. Cancer
|September 6, 2008
PubMed
Summary

Mammographic density (MD) is linked to breast cancer risk. Identifying genes that regulate MD may offer new insights into breast cancer development and prevention strategies.

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Last Updated: Jul 2, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland
06:29

Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland

Published on: June 7, 2019

Area of Science:

  • Genetics
  • Oncology
  • Radiology

Background:

  • Mammographic density (MD) is a significant risk factor for breast cancer.
  • MD is influenced by genetic factors, reflecting variations in breast tissue composition.
  • Understanding these genetic regulators could illuminate breast cancer etiology.

Purpose of the Study:

  • To review existing genetic studies on mammographic density.
  • To propose future research directions for identifying MD-regulating genes.
  • To explore the potential of MD genes as indirect breast cancer risk predictors.

Main Methods:

  • Literature review of genetic association studies concerning mammographic density.
  • Analysis of current understanding of gene regulation in breast tissue.
  • Synthesis of findings to identify knowledge gaps and future research avenues.

Main Results:

  • Limited genetic studies on MD have been published to date.
  • Several genes are implicated in regulating breast tissue composition and MD.
  • MD-regulating genes may be more readily identifiable than general breast cancer risk genes.

Conclusions:

  • Further genetic research into mammographic density is warranted.
  • Identifying MD genes could provide novel targets for breast cancer risk assessment.
  • Genetic insights into MD may offer a more focused approach to understanding breast cancer predisposition.