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Related Experiment Video

Updated: Jul 2, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Fast time-domain diffuse optical tomography using pseudorandom bit sequences.

Weirong Mo¹, Nanguang Chen

¹Division of Bioengineering, National University of Singapore, Singapore.

|September 6, 2008

Summary

This summary is machine-generated.

A new time-domain diffuse optical tomography system uses modulated near-infrared light for faster optical property measurements. This innovation shows promise for rapid, noninvasive breast cancer detection.

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Last Updated: Jul 2, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

A Protocol for Real-time 3D Single Particle Tracking

A Protocol for Real-time 3D Single Particle Tracking

Published on: January 3, 2018

High-Throughput Total Internal Reflection Fluorescence and Direct Stochastic Optical Reconstruction Microscopy Using a Photonic Chip

High-Throughput Total Internal Reflection Fluorescence and Direct Stochastic Optical Reconstruction Microscopy Using a Photonic Chip

Published on: November 16, 2019

Area of Science:

Biomedical Optics
Medical Imaging
Photonics

Background:

Diffuse optical tomography (DOT) is a promising imaging modality for noninvasive tissue characterization.
Conventional DOT systems often rely on ultrashort pulse lasers, limiting speed and increasing complexity.
Faster methods are needed for practical clinical applications, such as breast cancer detection.

Purpose of the Study:

To develop and validate a novel, high-speed time-domain diffuse optical tomography (TD-DOT) system.
To determine the optical properties of tissue-like phantoms more rapidly than conventional methods.
To assess the system's potential for clinical applications like breast cancer detection.

Main Methods:

Utilized a 2.5 Gbps pseudorandom bit sequence to modulate near-infrared light for illuminating tissue-like phantoms.
Employed demodulation with a reference signal to rapidly retrieve time-resolved optical signals.
Characterized the system's impulse response, achieving a full width at half maximum of approximately 800 picoseconds.

Main Results:

Achieved significantly faster acquisition of optical properties compared to conventional TD-DOT.
Generated 2-dimensional maps of optical properties within seconds.
Demonstrated a high signal-to-noise ratio and insensitivity to environmental illumination.

Conclusions:

The developed TD-DOT system offers rapid determination of optical properties.
Its speed, signal quality, and robustness make it suitable for clinical translation.
This technology holds significant potential for noninvasive breast cancer detection.