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[Quantitative and qualitative analysis of the blood flow in breast tumors using power Doppler ultrasound]
S Deyle1, H Jörn, H Schmid-Schönbein
1Frauenklinik für Gynäkologie und Geburtshilfe, Universitätsklinikum der Rheinisch-Westfälischen Technischen Hochschule Aachen. simone.deyle@ksli.ch
Purpose:
Our study was performed to obtain additional information regarding the present diagnostic approaches in breast tumor diagnosis by investigating tumor vessels. We present a new method that helps to capture the morphologic features from power Doppler ultrasound images using a computer-aided system facilitating pixel relation analysis techniques in the region of interest (ROI).
Materials And Methods:
45 solid breast tumors, including 18 benign and 27 malignant histologically proven cases, were studied using quantitative and qualitative parameters with extracted three-dimensional (3D) diagrams. We focused on pixel counting and on physiologic and pathophysiologic vascular analysis over time. P values less than 0.05 using the Wilcoxon, Mann and Whitney's U-test were deemed statistically significant.
Results:
One of the two quantitative values, the color range, showed a statistical significance for distinguishing between benign and malignant lesions by counting more pixels in malignant cases. We detected differences in the blood flow dynamics with a characteristic flow texture in 89 % of benign lesions and periodic oscillations which were identified with a diagnostic accuracy of 78 % in malignant cases.
Conclusion:
The preliminary results show that the proposed method using power Doppler imaging is feasible and can aid in the classification of breast tumors as benign or malignant.
