Sexual dysfunction as a complication of treatment of gestational trophoblastic neoplasia

To examine the impact of gestational trophoblastic neoplasia (GTN) therapy on women's sexuality.

A questionnaire concerning various sexual problems experienced by patients treated with chemotherapy and/or surgery for GTN and in remission for 1 year or more was completed by 47 women in the outpatient clinic of the Trophoblastic Disease Section of our institution from January to June 2007.

Ninety-five percent of the subjects continued sexual activity after treatment, but there was an increase in the incidence of sexual problems, which resulted in a slight reduction in the quality of their sex lives. Seventy percent of the women experienced absent or low sexual desire, while 42% had dyspareunia and 45% had lubrication problems. Fifty-three percent experienced changes in the relationship with their partner within the first year after remission.

Sexual dysfunction is a common complication of treatment of GTN yet is given little attention as compared to other complications. Patient education and reassurance, with early diagnosis and intervention, are essential for a better quality of life for survivors.