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Updated: Jul 2, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Fatal liver failure: molecular evidence for chronic active Epstein-Barr virus infection
Francesca Sánchez1, Juan Luis Gimeno-Bayón, Raquel Esgueva
1Services of Internal Medicine and Infectious Diseases, Hospital del Mar. Barcelona, 08003 Barcelona, Spain. psanchez@aspb.es
Abstract:
Epstein-Barr virus (EBV) infection is a benign disease, which may occasionally be fatal, particularly in children and immunocompromised patients. Epstein-Barr virus infection is rare in elderly subjects and seems to have a self-limited course. A case of fatal liver failure due to chronic active EBV infection in a 75-year-old man is described. The etiology was established postmortem by cellular expression of EBV-DNA in liver and lymphatic tissue. This patient meets the diagnostic criteria of a case definition for a highly probable "severe chronic active EBV syndrome." Either suspected or unsuspected, the long-term prognosis of this syndrome is poor and its mortality high.
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