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CD147 expression as a significant prognostic factor in differentiated thyroid carcinoma.

Hui Tan1, Ke Ye, Zhiming Wang

  • 1Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Translational Research : the Journal of Laboratory and Clinical Medicine
|September 9, 2008
PubMed
Summary

High CD147 expression in differentiated thyroid carcinoma (DTC) correlates with poorer patient prognosis. This study found CD147 is a potential independent prognostic indicator for DTC, aiding in predicting patient outcomes.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Pathology

Background:

  • CD147 is a molecule implicated in regulating matrix metalloproteinases (MMPs).
  • Understanding CD147's role in differentiated thyroid carcinoma (DTC) is crucial for prognosis.
  • Previous research has not fully elucidated CD147's prognostic significance in DTC.

Purpose of the Study:

  • To analyze CD147 expression in DTC tissues.
  • To investigate the association between CD147 expression and clinicopathologic features of DTC.
  • To determine the prognostic significance of CD147 in DTC patients.

Main Methods:

  • Immunohistochemical staining of CD147 on paraffin-embedded tumor specimens from 156 DTC patients (100 PTC, 56 FTC).
  • Statistical analysis correlating CD147 expression levels with clinicopathologic characteristics.

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  • Survival analysis and Cox regression to identify independent prognostic indicators.

    • Main Results:

    • CD147 was expressed in DTC cancerous lesions but not in normal thyroid tissues.
    • Positive CD147 staining significantly correlated with extrathyroidal invasion, lymph node metastasis, and tumor invasion depth.
    • Patients with low CD147 expression demonstrated significantly better survival rates compared to those with intermediate and high expression.

    Conclusions:

    • CD147 expression is significantly associated with aggressive clinicopathologic features in DTC.
    • High CD147 expression is an independent indicator of poor prognosis in DTC patients.
    • CD147 expression levels may serve as a valuable biomarker for predicting DTC patient prognosis.