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Related Concept Videos

Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: Jul 2, 2026

Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain
07:27

Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain

Published on: July 18, 2016

[Central post-stroke pain].

S Demasles1, R Peyron, L Garcia Larrea

  • 1Centre stéphanois de la douleur et service de neurologie, hôpital de Bellevue, 42055 Saint-Etienne cedex 02, France. sdemasles@hotmail.com

Revue Neurologique
|September 9, 2008
PubMed
Summary
This summary is machine-generated.

Central post-stroke pain (CPSP) remains poorly understood but recent advances in neuroimaging and pain pathway analysis offer new insights. Motor cortex stimulation shows promise for treating CPSP by modulating pain control areas.

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Last Updated: Jul 2, 2026

Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain
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Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

Area of Science:

  • Neurology
  • Pain Medicine
  • Neuroscience

Context:

  • Central post-stroke pain (CPSP), historically linked to Dejerine-Roussy syndrome, lacks updated descriptions.
  • Recent advancements in neuroimaging, including MRI and fMRI, have revitalized research into CPSP.
  • Understanding of pain pathways has improved through techniques like laser-evoked potentials and opioid receptor studies.

Purpose:

  • To review recent advancements in understanding and treating Central Post-Stroke Pain (CPSP).
  • To highlight the role of neuroimaging and neurophysiological techniques in studying CPSP.
  • To discuss emerging therapeutic strategies for CPSP.

Summary:

  • CPSP research has been reinvigorated by neuroimaging (MRI, fMRI) and neurophysiological tools (laser-evoked potentials).
  • Studies on opioid receptors and pain pathways have enhanced our comprehension of CPSP.
  • The thalamus is identified as a key structure in the central pain control disorder of CPSP.
  • Motor cortex stimulation represents a novel neuromodulation approach for CPSP treatment.

Impact:

  • Advances in neuroimaging and neurophysiology provide a deeper understanding of CPSP.
  • Motor cortex stimulation offers a promising new avenue for CPSP management.
  • This research paves the way for improved neuromodulation therapies targeting pain pathways.