Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 2, 2026

Facial Nerve Surgery in the Rat Model to Study Axonal Inhibition and Regeneration
05:04

Facial Nerve Surgery in the Rat Model to Study Axonal Inhibition and Regeneration

Published on: May 5, 2020

Cavernous nerve injury using rodent animal models.

Onder Canguven1, Arthur Burnett

  • 1James Buchanan Brady Urological Institute, The Johns Hopkins Hospital-Urology, Baltimore, MD 21287-2411, USA. ocanguv1@jhmi.edu

The Journal of Sexual Medicine
|September 9, 2008
PubMed
Summary

Rodent models of cavernous nerve (CN) injury help researchers understand erectile dysfunction after pelvic surgery. These models reveal molecular, morphological, and physiological changes, aiding in recovery insights.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A comparative evaluation of on-demand phosphodiesterase-5 inhibitor efficacy in erectile dysfunction treatment: a systematic review and network meta-analysis of double-blind, placebo-controlled, randomized trials.

The journal of sexual medicine·2026
Same author

Health consequences of anabolic steroids: a sexual-medicine perspective.

International journal of impotence research·2026
Same author

A clinically oriented algorithm for cylinder and extender selection in the penoscrotal approach: the Canguven penile prosthesis calculator.

The journal of sexual medicine·2026
Same author

Use of oral phosphodiesterase type-5 inhibitors before penile prosthesis implantation: duration, predictors, and clinical insights.

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica·2026
Same author

Does age matter? Impact of age on testicular function and pregnancy outcomes following microsurgical varicocelectomy in patients with grade 3 varicocele.

Arab journal of urology·2025
Same author

Are sexually transmitted infections associated with male infertility? A systematic review and in-depth evaluation of the evidence and mechanisms of action of 11 pathogens.

Arab journal of urology·2024

Area of Science:

  • Urology
  • Surgical Innovation
  • Experimental Medicine

Background:

  • Nerve-sparing techniques improve erectile function post-pelvic surgery, but recovery rates vary widely (9-86%).
  • Cavernous nerve (CN) injury remains a challenge despite surgical advancements.
  • Pathophysiology of surgical erectile dysfunction is not fully understood.

Purpose of the Study:

  • To review experimental models of CN injury in small rodents.
  • To describe both survival and non-survival surgical models.
  • To critique techniques, highlighting advantages and disadvantages.

Main Methods:

  • Literature search using PubMed with terms 'cavernous nerve injury' and 'animal model'.
  • Manual review of cross-referenced articles.

More Related Videos

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve
07:00

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve

Published on: November 14, 2025

Related Experiment Videos

Last Updated: Jul 2, 2026

Facial Nerve Surgery in the Rat Model to Study Axonal Inhibition and Regeneration
05:04

Facial Nerve Surgery in the Rat Model to Study Axonal Inhibition and Regeneration

Published on: May 5, 2020

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve
07:00

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve

Published on: November 14, 2025

  • Focus on peer-reviewed literature.

    • Main Results:

    • Rodent models allow measurement of molecular, morphological, and physiological changes post-CN injury.
    • Various experimental procedures are employed in these models.

    Conclusions:

    • Established CN injury models in rodents provide valuable insights into erectile function recovery.
    • These models are crucial for understanding and potentially improving outcomes.