Related Experiment Video
Updated: Jul 1, 2026

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
Published on: November 1, 2011
Regulating antibody diversity: taming a mutagen
Patricia J Gearhart1, Ranjan Sen
1Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA. gearhartp@grc.nia.nih.gov
Abstract:
In a recent issue of Molecular Cell, Conticello et al. (2008) identified a protein that interacts with the activation-induced deaminase protein and affects somatic hypermutation, class switching, and gene conversion in immunoglobulin genes, possibly via the spliceosome transcription complex.
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