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Related Concept Videos

Transcription Elongation Factors02:35

Transcription Elongation Factors

Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA into a...
Transcription Elongation Factors02:35

Transcription Elongation Factors

Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA into a...
Transcription Attenuation in Prokaryotes02:42

Transcription Attenuation in Prokaryotes

Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure.  Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription01:17

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...

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Related Experiment Video

Updated: Jul 1, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Transcriptional ShortCUTs.

Bernhard Dichtl1

  • 1Institute of Molecular Biology, University of Zürich, CH-8057 Zürich, Switzerland. bernhard.dichtl@molbio.uzh.ch

Molecular Cell
|September 9, 2008
PubMed
Summary

Regulated expression of nucleotide synthesis pathway components controls RNA polymerase II termination. This finding reveals a link between nucleotide availability and gene expression regulation.

Area of Science:

  • Molecular Biology
  • Gene Expression
  • RNA Polymerase II Transcription

Background:

  • RNA polymerase II (Pol II) termination is a critical step in gene expression.
  • The precise mechanisms regulating Pol II termination are still being elucidated.
  • Nucleotide synthesis pathways are essential for DNA and RNA production.

Discussion:

  • Recent studies demonstrate that the expression of genes involved in nucleotide synthesis influences Pol II termination.
  • This regulation appears to be dependent on the transcription start site.
  • This suggests a coordinated control between metabolic pathways and gene expression.

Key Insights:

  • Regulated expression of central nucleotide synthesis pathway components directs start site-dependent RNA polymerase II termination.

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Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms
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Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Published on: September 13, 2018

Extremely Rapid and Specific Metabolic Labelling of RNA In Vivo with 4-Thiouracil (Ers4tU)
11:46

Extremely Rapid and Specific Metabolic Labelling of RNA In Vivo with 4-Thiouracil (Ers4tU)

Published on: August 22, 2019

Related Experiment Videos

Last Updated: Jul 1, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms
09:30

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Published on: September 13, 2018

Extremely Rapid and Specific Metabolic Labelling of RNA In Vivo with 4-Thiouracil (Ers4tU)
11:46

Extremely Rapid and Specific Metabolic Labelling of RNA In Vivo with 4-Thiouracil (Ers4tU)

Published on: August 22, 2019

  • This provides a novel mechanism linking cellular metabolism to transcriptional regulation.
  • The findings highlight the intricate crosstalk between nucleotide pools and gene expression control.

    • Outlook:

    • Further research is needed to identify the specific molecular players mediating this termination control.
    • Investigating how this mechanism impacts cellular responses to metabolic stress could be a future direction.
    • Understanding this interplay may offer new therapeutic targets for diseases involving altered gene expression and metabolism.