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Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Riboswitches01:56

Riboswitches

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Related Experiment Video

Updated: Jul 1, 2026

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

Artificial molecular switches made from DNA.

Eike Friedrichs1, Angeliki Tsokou, Ralf Jungmann

  • 1Lehrstuhl für Bioelektronik, Technische Universität München, Physik Department, James-Franck-Strasse, 85748 Garching, Germany.

Nucleic Acids Symposium Series (2004)
|September 9, 2008
PubMed
Summary

DNA

Area of Science:

  • Biochemistry
  • Biophysics
  • Nanotechnology

Background:

  • DNA's unique properties enable nanoscale machine construction.
  • Aptamer-based devices offer controllable enzyme binding and release.
  • DNA is a component in switchable materials like gels.

Purpose of the Study:

  • To explore DNA's utility in creating nanoscale machines and switches.
  • To investigate DNA nanodevices for controlling biochemical reactions and materials.
  • To examine the interaction of DNA nanodevices with RNA and gene regulatory mechanisms.

Main Methods:

  • Utilizing DNA's biochemical and biophysical properties.
  • Developing aptamer-based switchable devices.
  • Constructing DNA-based switchable gels.

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  • Investigating DNA nanodevice interactions with RNA.

    • Main Results:

    • DNA nanomachines can perform functions like stretching, rotating, and translocation.
    • Switchable aptamer devices enable controlled enzyme binding/release for reaction control.
    • DNA-based gels offer potential for controlled release applications.
    • DNA nanodevices can be influenced by gene regulatory mechanisms.

    Conclusions:

    • DNA nanostructures offer versatile platforms for nanoscale devices and materials.
    • Aptamer-based systems provide precise control over biochemical processes.
    • DNA nanodevices hold promise for applications in controlled release and gene regulation.