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Updated: Jul 1, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
Published on: April 10, 2026
Rearranged and unrearranged angucyclinones from Indonesian Streptomyces spp
Serge Fotso1, Taifo Mahmud, T Mark Zabriskie
1Department of Pharmaceutical Sciences, College of Pharmacy, Corvallis, Oregon 97331-3507, USA.
Abstract:
Two Indonesian Streptomyces strains, ICBB8309 and ICBB8415, were investigated for their ability to produce antibiotic compounds. In addition to the known antibiotics actiphenol, naramycin B, and sabaramycin, six new angucyclinones were identified. The isolation, structure elucidation and biological activities for the six new compounds are presented. The angucyclinones 7-deoxo-6-deoxy-7-hydroxy-8-O-methylrabelomycin, 1-deoxo-1-hydroxy-8-O-methylrabelomycin, and the angucycline 7-deoxo-7-hydroxy-1-O-alpha-rhamnosyl-8-O-methyltetrangulol have common angular backbones, while angucyclinone C, limamycin A, and limamycin B appear to be rearranged angucyclinones.
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