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Derivatives of reactive oxygen metabolites correlates with high-sensitivity C-reactive protein
Fumihiko Kamezaki1, Kazuhito Yamashita, Takahiro Kubara
1The Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Insights
High-sensitivity C-reactive protein (hsCRP) predicts cardiovascular events. This study found that higher hsCRP levels correlate with increased oxidative stress markers (D-ROMs) in patients with coronary artery disease.
Area of Science:
- Cardiology
- Biochemistry
- Biomarkers
Background:
- High-sensitivity C-reactive protein (hsCRP) is a recognized predictor of cardiovascular events.
- Oxidative stress is implicated in cardiovascular disease, but its relationship with hsCRP requires further investigation.
- Few studies have directly compared hsCRP, serum lipids, and oxidative stress markers in patients with coronary artery disease.
Purpose of the Study:
- To investigate the association between hsCRP, serum lipids, and derivatives of reactive oxygen metabolites (D-ROMs) in patients with coronary artery disease.
- To determine if oxidative stress markers are elevated in individuals with higher hsCRP levels, indicating increased cardiovascular risk.
Main Methods:
- Serum lipids, hsCRP, plasma brain natriuretic peptides (BNP), and D-ROMs were measured in 131 patients undergoing cardiac catheterization.
- Patients were stratified into three groups based on hsCRP levels: <1.0 mg/L, 1.0-3.0 mg/L, and >3.0 mg/L.
- Statistical analyses were performed to assess correlations and identify independent predictors of hsCRP.
Main Results:
- Patients in the highest hsCRP group (>3.0 mg/L) exhibited significantly higher mean D-ROMs levels compared to lower hsCRP groups.
- A significant positive correlation was observed between serum D-ROMs and hsCRP levels (r=0.479, p<0.0001).
- D-ROMs, HDL-C, LDL-C, and log-transformed BNP were identified as independent predictors of hsCRP.
Conclusions:
- Oxidative stress is elevated in patients with coronary artery disease who are at high risk, as indicated by elevated hsCRP levels.
- These findings suggest that oxidative stress contributes to cardiovascular risk in a manner associated with hsCRP.
- The study highlights the interplay between inflammation and oxidative stress in the pathogenesis of cardiovascular disease.
Aim:
High-sensitivity C-reactive protein (hsCRP) is a predictor of cardiovascular events. Although oxidative stress may also be related to cardiovascular disease, there are few studies comparing the two. We therefore examined the association of hsCRP, serum lipids, and derivatives of reactive oxygen metabolites (D-ROMs) in coronary artery disease.
Methods:
We measured the levels of serum lipids, hsCRP, plasma brain natriuretic peptides (BNP) and D-ROMs in 131 consecutive patients undergoing cardiac catheterization. We divided these subjects into three groups according to their levels of hsCRP.
Results:
In group C (hsCRP>3.0 mg/L), mean levels of serum D-ROMs were significantly higher than in groups A (hsCRP<1.0 mg/L) and B (hsCRP 1.0 to 3.0 mg/L). Serum levels of D-ROMs and log (hsCRP) correlated in the total population (r=0.479, p<0.0001), and D-ROMs, HDL-C, LDL-C and log-transformed plasma BNP were independent predictors of hsCRP (p<0.0001).
Conclusion:
We concluded that oxidative stress increases in patients at high risk for cardiovascular events based on their hsCRP.
