Related Experiment Video

Updated: Jul 1, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Severity of obstructive sleep apnea in children with sickle cell disease

Joseph Kaleyias1, Navid Mostofi, Mitzie Grant

  • 1Sections of Neurology and Sleep Medicine, St Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, PA, USA.

Journal of Pediatric Hematology/Oncology
|September 9, 2008
PubMed

Insights

Children with sickle cell disease (SCD) and suspected sleep disordered breathing (SDB) show a higher incidence and severity of obstructive sleep apnea syndrome (OSAS), including significant nocturnal desaturation and hypercapnia.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Hematology

Background:

  • Sleep disordered breathing (SDB) is a concern in children with sickle cell disease (SCD).
  • Polysomnography (PSG) is crucial for diagnosing SDB and its severity.

Purpose of the Study:

  • To characterize polysomnographic (PSG) findings in children with SCD who exhibit symptoms suggestive of SDB.
  • To compare PSG results between children with SCD and obstructive sleep apnea syndrome (OSAS) and those with uncomplicated OSAS.

Main Methods:

  • 100 children with SCD completed a sleep habit questionnaire; 48 showed SDB suspicion.
  • 19 children with SCD underwent overnight PSG.
  • PSG results were compared between the SCD-OSAS group and an age, sex, and ethnicity-matched uncomplicated OSAS group.

Main Results:

  • SDB was identified in 79% of the SCD group.
  • The SCD-OSAS group experienced more severe nocturnal desaturation (lower nadir, longer duration, increased risk of SpO2 <85%) compared to the uncomplicated OSAS group.
  • The SCD-OSAS group showed significantly higher end-tidal carbon dioxide (ET CO2) levels, indicating increased hypercapnia.

Conclusions:

  • Children with SCD and suspected SDB have a higher prevalence of OSAS.
  • These children present with more severe nocturnal desaturation and hypercapnia than those with uncomplicated OSAS.
Abstract

More Related Videos

Acupoint Application Combined with Ear Plaster Therapy for Treating Sleep Disorders with Acute Exacerbation of Chronic Obstructive Pulmonary Disease04:53

Acupoint Application Combined with Ear Plaster Therapy for Treating Sleep Disorders with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Published on: October 18, 2024

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...