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Updated: Jul 1, 2026
10:14
Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
[Amaurosis fugax: case report].
Joanna Kur-Zalewska1, Mateusz Tłustochowicz, Witold Tłustochowicz
1Klinika Chorób Wewnetrznych i Reumatologii, Wojskowy Instytut Medyczny, Warszawa. a.kur_zalewska@reumatologia.org.pl
Polskie Archiwum Medycyny Wewnetrznej
|September 10, 2008
Summary
Systemic lupus erythematosus (SLE) with high anticardiolipin antibodies (aCL) can cause sudden vision loss. Prompt treatment with anticoagulation, steroids, and cyclophosphamide improved visual function in a patient.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- Anticardiolipin antibodies (aCL) are associated with an increased risk of thrombosis.
- Ocular manifestations in SLE can be diverse and impact visual function.
Observation:
- A 27-year-old woman with SLE and high-titer IgG anticardiolipin antibodies presented with sudden bilateral vision loss.
- The patient's presentation suggested acute optic neuropathy.
Findings:
- The optic neuropathy was likely associated with the SLE flare and anticardiolipin antibodies.
- Treatment involved anticoagulation, high-dose steroids, and intravenous cyclophosphamide.
Implications:
- This case highlights a potential cause of sudden vision loss in patients with SLE and aCL.
- Aggressive immunosuppressive and anticoagulant therapy may be effective in managing this sight-threatening complication.
- Early diagnosis and intervention are crucial for preserving visual function in such cases.
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