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Using risperidone for Alzheimer's dementia-associated psychosis
Karleen M McNeal1, Renee P Meyer, Karen Lukacs
1Alzheimer's Research and Clinical Programs, VA Medical Center and Medical University of South Carolina, Geriatrics and Extended Care, Charleston, SC, 29406-6076, USA.
Expert Opinion on Pharmacotherapy
|September 10, 2008
Summary
Risperidone is a common choice for Alzheimer's dementia (AD) psychosis, despite safety concerns. It may offer behavioral benefits for AD patients with severe agitation and aggression.
Area of Science:
- Geriatric Psychiatry
- Neuroscience
- Pharmacology
Background:
- Alzheimer's dementia (AD) affects 6-8% of individuals over 65, rising to 30% in those over 85.
- Psychosis occurs in 30-50% of AD patients, necessitating careful psychotropic agent use.
- Safe and effective management of psychosis in AD is a significant clinical challenge.
Purpose of the Study:
- To review the risks and benefits of using risperidone for psychosis associated with Alzheimer's dementia.
- To evaluate the clinical efficacy and safety profile of risperidone in this patient population.
Main Methods:
- Comprehensive literature review.
- Analysis of clinical experience with risperidone in AD patients.
- Discussion of efficacy, safety, and regulatory aspects.
Main Results:
- Risperidone is frequently prescribed for AD-associated psychosis.
- Potential for greater behavioral benefit in patients with severe agitation and aggression.
- Safety concerns remain a consideration in treatment decisions.
Conclusions:
- Risperidone continues to be a widely used option for managing psychosis in Alzheimer's dementia.
- Careful patient selection may optimize therapeutic outcomes.
- Balancing efficacy and safety is crucial for risperidone treatment in AD.
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