Related Experiment Video
Updated: Jul 1, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
Thalidomide-Related Eosinophilic Pneumonia: A case report and brief literature review
Lisa Tilluckdharry1, Robert Dean, Carol Farver
1Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA. tillucl@ccf.org.
Abstract:
Thalidomide has regained value in the multimodality treatment of leprosy, multiple myeloma, prostate, ovarian and renal cancer. Complications related to arterial and venous complications are well described. However, pulmonary complications remain relatively uncommon. The most common pulmonary side-effect reported is non-specific dyspnea. We report a patient with multiple myeloma, who developed an eosinophilic pneumonia, shortly after starting thalidomide. She had complete resolution of her symptoms and pulmonary infiltrates on discontinuation of the drug and treatment with corticosteroids. Physicians should be cognizant of this potential complication in patients receiving thalidomide who present with dyspnea and pulmonary infiltrates.
Related Concept Videos
Asthma I: Introduction
Drug toxicity: Idiosyncratic Reactions
Teratogenicity
Toxoplasmosis
Asthma III: Clinical Manifestations
Atypical Pneumonia