[Assessment of tissue platinum concentration, X-ray computed tomogram, and microangiography after CDDP...

After intraperitoneal administration of cis-diamine-dichloroplatinum, tissue Pt concentration, dynamic CT, and microangiography were estimated in white rabbit model having been transplanted with VX2 ovarian tumor. The high Pt concentration resulting from CDDP intraperitoneal administration was recognized in kidney, liver, and VX2 ovarian tumor. CT scans demonstrated that CDDP administration inhibited the development of VX2 tumor, revealing the appearance of small areas with no enhancement corresponding to necrotic regions in the tumor external rim. A tumor time-density curve showed a significantly delayed washout of the excretory phase following CDDP administration. Regarding microangiography models, tumor vessels of less than 30 microns decreased. It was suggested that the tumor microcirculation diminished because of the increased tissue pressure concomitant with tumor necrosis.