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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

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Parathyroid hormone and the cardiovascular system.

Lorraine A Fitzpatrick¹, John P Bilezikian, Shonni J Silverberg

¹Research and Development, Musculoskeletal Diseases, GlaxoSmithKline, 2301 Renaissance Boulevard, RN0420, King of Prussia, PA 19406, USA. lorraine.a.fitzpatrick@gsk.com

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|September 10, 2008

Summary

Parathyroid hormone (PTH) has known effects, but its cardiovascular impacts are underappreciated. This review examines PTH

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Published on: March 14, 2017

Area of Science:

Endocrinology
Cardiovascular Medicine
Cellular Biology

Background:

Parathyroid hormone (PTH) classically regulates calcium and phosphate homeostasis.
Emerging evidence suggests PTH influences non-classical target tissues, including the cardiovascular system.
Primary hyperparathyroidism provides a model to study PTH's systemic effects.

Purpose of the Study:

To review the cardiovascular effects of parathyroid hormone (PTH).
To evaluate the association between PTH and hypertension, cardiovascular mortality, and cardiac function.
To explore the underlying cellular mechanisms of PTH's cardiovascular actions.

Main Methods:

Systematic review of studies on primary hyperparathyroidism and cardiovascular outcomes.
Analysis of data concerning blood pressure, mortality rates, and cardiac function.
Evaluation of proposed cellular and molecular pathways involved in PTH signaling.

Main Results:

Studies in primary hyperparathyroidism suggest a link between elevated PTH and hypertension.
Evidence indicates potential associations with increased cardiovascular mortality.
Alterations in left ventricular and endothelial function are observed in hyperparathyroid states.

Conclusions:

Parathyroid hormone (PTH) exerts significant, though often overlooked, effects on the cardiovascular system.
Understanding these effects is crucial for managing patients with hyperparathyroidism.
Further research into cellular mechanisms can guide therapeutic strategies.