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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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S Manolopoulos¹, C Wojnecki, S Green

¹Department of Medical Physics, University Hospital Birmingham NHS Trust, Birmingham B15 2TH, UK. s.manolopoulos@bham.ac.uk

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Summary

Contrast-enhanced radiotherapy (CERT) uses high-Z media for localized dose enhancement. This study adapted treatment planning software to demonstrate dose increases in brain tumors using iodinated contrast, validating CERT

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Area of Science:

Medical Physics
Radiation Oncology
Radiotherapy Physics

Background:

Contrast-enhanced radiotherapy (CERT) aims for biologically localized dose enhancement.
This relies on preferential uptake of high-Z contrast media by tumor cells.
Effective treatment planning is crucial for optimizing CERT delivery.

Purpose of the Study:

To adapt existing treatment planning software for evaluating CERT plans.
To assess the dosimetric impact of iodinated contrast media in a realistic brain tumor scenario.
To quantify dose enhancement factors for varying contrast concentrations.

Main Methods:

Utilized treatment planning software originally developed for Boron Neutron Capture Therapy (BNCT).
Created a realistic brain tumor test case based on actual CT scan data.
Calculated dose distributions with and without iodinated contrast medium.
Determined dose enhancement factors at various depths and concentrations.

Main Results:

Observed a consistent dose enhancement at all depths with the introduction of iodine.
Quantified dose enhancement factors, demonstrating a concentration-dependent effect.
Validated the capability of the adapted software for CERT plan evaluation.

Conclusions:

The adapted BNCT treatment planning software is suitable for evaluating CERT.
Iodinated contrast media significantly enhance radiation dose in tumor volumes.
CERT shows potential for improving radiotherapy efficacy through targeted dose escalation.