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Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer
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ERRalpha: a metabolic function for the oldest orphan.

Josep A Villena1, Anastasia Kralli

  • 1Institut de Recerca Hospital Universitari Vall d'Hebron, Grup de Metabolisme i Obesitat, Barcelona, Spain.

Trends in Endocrinology and Metabolism: TEM
|September 10, 2008
PubMed
Summary
This summary is machine-generated.

Estrogen receptor related receptor alpha (ERRalpha) is crucial for adaptive energy metabolism. Targeting ERRalpha may offer new strategies for treating metabolic diseases.

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Metabolism Research

Background:

  • Estrogen receptor related receptor (ERR)alpha, identified in 1988, is an orphan nuclear receptor.
  • Unlike many other orphan nuclear receptors, ERRalpha's function in metabolic pathways remained largely undefined for decades.
  • Recent research has begun elucidating ERRalpha's regulatory mechanisms and transcriptional targets, highlighting its role in metabolism.

Purpose of the Study:

  • To define the role of ERRalpha in adaptive energy metabolism.
  • To investigate the consequences of ERRalpha deficiency under metabolic stress.
  • To explore the therapeutic potential of targeting ERRalpha for metabolic diseases.

Main Methods:

  • Utilized mouse models lacking ERRalpha.
  • Subjected mice to various metabolic stressors including cold exposure, cardiac overload, and infection.
  • Analyzed metabolic responses and physiological outcomes in wild-type versus ERRalpha-deficient mice.

Main Results:

  • Mice lacking ERRalpha exhibited significant defects in energy metabolism when challenged with stressors.
  • These defects indicate ERRalpha's critical role in facilitating metabolic adjustments during stress.
  • Specific metabolic pathways regulated by ERRalpha were identified.

Conclusions:

  • Estrogen receptor related receptor alpha is essential for adaptive energy metabolism.
  • ERRalpha plays a vital role in an organism's ability to 'shift gears' metabolically under stress.
  • Targeting ERRalpha presents a promising avenue for developing novel treatments for metabolic diseases.