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Postoperative biochemical liver function after major hepatic resection in children
Paul Needham1, Dowmitra Dasgupta, John Davies
1Department of Surgery, St James's University Hospital, Leeds LS9 7TF, UK.
Journal of Pediatric Surgery
|September 10, 2008
Summary
Pediatric liver function tests (LFTs) normalize faster after major liver resection than in adults. Preoperative chemotherapy does not significantly impact LFT recovery profiles in children undergoing liver surgery.
Area of Science:
- Pediatric Surgery
- Hepatology
- Biochemistry
Background:
- Limited data exists on biochemical liver function test (LFT) profiles post-partial hepatectomy in children.
- Understanding these profiles is crucial for managing pediatric liver resections.
Purpose of the Study:
- Establish normal LFT profiles after major liver resection in non-cirrhotic children.
- Analyze the impact of preoperative chemotherapy on LFT recovery.
Main Methods:
- Retrospective analysis of clinical and biochemical data from children undergoing major liver resection for hepatic tumors.
- Comparison of LFTs based on resection extent (≥4 segments vs. lesser) and presence of preoperative chemotherapy.
Main Results:
- Peak LFT derangements occurred on postoperative days 1-2.
- Bilirubin and albumin normalized by day 5; INR and alkaline phosphatase by day 7; ALT by 1-2 weeks.
- More extensive resections correlated with higher peak ALT and INR; preoperative chemotherapy showed no significant effect on recovery.
Conclusions:
- Postoperative LFTs in children resolve more rapidly than in adults following partial hepatectomy.
- Preoperative chemotherapy does not substantially alter post-resection LFT profiles in pediatric patients.
