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Updated: Jul 1, 2026
05:14
Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography
Published on: August 11, 2023
Lacquer crack formation and choroidal neovascularization in pathologic myopia.
Yasushi Ikuno1, Kaori Sayanagi, Kaori Soga
1Department of Ophthalmology, Osaka University Medical School, Osaka, Japan. ikuno@ophthal.med.osaka-u.ac.jp
Retina (Philadelphia, Pa.)
|September 10, 2008
Summary
Lacquer crack (LC) formation is crucial for the development of classic myopic choroidal neovascularization (mCNV). Indocyanine green angiography (ICGA) with HRA2 provides detailed insights into mCNV and LC characteristics.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Myopic choroidal neovascularization (mCNV) is a significant cause of vision loss in high myopia.
- Lacquer cracks (LCs) are common findings in highly myopic eyes and are thought to be related to chorioretinal stress.
Purpose of the Study:
- To characterize choroidal neovascularization (CNV) in myopic eyes (mCNV).
- To investigate the relationship between lacquer crack (LC) formation and the development of mCNV.
Main Methods:
- Thirty-seven eyes with mCNV were evaluated using fluorescein angiography (FA) and indocyanine green angiography (ICGA) with Heidelberg Retina Angiograph 2 (HRA2).
- mCNV and LCs were identified and characterized based on angiographic findings, with LCs specifically detected by late-phase ICGA.
Main Results:
- Classic mCNV was present in 95% of eyes, while occult CNV was found in 5%.
- LCs were observed in 95% of eyes, and in most cases (94%), classic mCNV originated from these LCs.
- No association was found between occult CNV and LCs. Two LC morphologies (linear and stellate) were observed, with no significant clinical differences.
- Well-delineated hyperfluorescence on late-phase ICGA, potentially indicating activity, was correlated with the absence of a dark rim.
Conclusions:
- ICGA using HRA2 offers superior detail for assessing mCNV and LCs.
- LC formation is a prerequisite for the development of classic mCNV.
- While LC morphology varies, it does not appear to have distinct clinical implications for mCNV development. Late-phase hyperfluorescence may signify active mCNV.
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