Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Placebo Effect01:54

The Placebo Effect

The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Treatment Strategies for Psychological Disorders01:24

Treatment Strategies for Psychological Disorders

Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
Blind Procedures02:07

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
Cognitive Therapy01:25

Cognitive Therapy

Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From inflammation to inheritance: rethinking myocarditis as the first signal of desmosomal cardiomyopathy.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology·2026
Same author

Modular training resources for bioimage analysis.

Journal of microscopy·2026
Same author

Deciphering Mental Illness: Neurons vs. Neuroglia.

Journal of clinical psychopharmacology·2026
Same author

A Material Roadmap for Translational and Sustainable Point-of-Care Diagnostics Through Bacterial Cellulose: A Comprehensive Review.

ACS applied bio materials·2026
Same author

Liposomal Methylglyoxal Targets Virulence and Intracellular Persistence to Overcome Amphotericin B Resistance in <i>Cryptococcus neoformans</i>.

International journal of molecular sciences·2026
Same author

Efficacy and Safety of the Selective, Brain-Penetrant P2X7 Receptor Antagonist JNJ-55308942 (Zanvipixant) in Bipolar Depression: A Phase 2a Study.

Biological psychiatry global open science·2026

Related Experiment Video

Updated: Jul 1, 2026

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
08:50

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

Published on: December 14, 2014

Placebo response in depression: a perspective for clinical practice.

Arif Khan1, Shirin Khan

  • 1Northwest Clinical Research Center, Bellevue, WA, USA. akhan@nwcrc.net

Psychopharmacology Bulletin
|September 10, 2008
PubMed
Summary

Antidepressant effectiveness research has methodological flaws. Despite doubts, current data still support antidepressants for treating major depressive disorder.

More Related Videos

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
10:54

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

Related Experiment Videos

Last Updated: Jul 1, 2026

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
08:50

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

Published on: December 14, 2014

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
10:54

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

Area of Science:

  • Clinical Psychiatry
  • Pharmacology
  • Research Methodology

Background:

  • Depression management remains challenging despite numerous pharmacological and non-pharmacological treatments.
  • Existing treatments often fail to provide complete symptom relief, impacting patient morbidity and mortality.
  • Recent studies question the therapeutic index of antidepressants due to methodological concerns.

Purpose of the Study:

  • To critically evaluate recent research on antidepressant effectiveness.
  • To highlight methodological deficits and biased interpretations in published studies.
  • To provide clinicians with a clearer perspective on antidepressant use.

Main Methods:

  • Review and critique of recent methodological research on antidepressant effectiveness.
  • Analysis of potential biases and limitations in study interpretations.
  • Synthesis of available data, including published and unpublished findings.

Main Results:

  • Methodological issues in recent studies cast doubt on the established therapeutic index of antidepressants.
  • Biased interpretations in research may obscure the true effectiveness of these medications.
  • Despite critiques, a robust body of evidence supports the use of antidepressants.

Conclusions:

  • Clinically depressed patients require effective treatment options.
  • Antidepressants remain a recommended treatment based on the most reliable available data.
  • Further high-quality research is needed to refine understanding of antidepressant efficacy and safety.