Related Experiment Video
Updated: Jul 1, 2026
3D Imaging of PDL Collagen Fibers during Orthodontic Tooth Movement in Mandibular Murine Model
Published on: April 15, 2021
[Effects of orthodontic tooth movements on insulin-like growth factors expression in periodontal tissues]
Jie Guo1, Qing Zhao, Yang-xi Chen
1Dept. of Orthodontics, School of Stomatology, Shandong University, Jinan 250012, China.
Objective:
To elucidate the regulatory bio-mechanism of estrogen and local stress on the bone remodeling activities in vivo.
Methods:
A Wistar rat experimental model was established to apply orthodontic activation during different stages of estrous cycle. In situ hybridization was used to detect the variation of the insulin-like growth factors (IGF) mRNA expression in the periodontal tissues. The data of each group was analyzed with SPSS 11.0 software package for Student-Newman-Keuls (S-N-K) test and one way ANOVA test.
Results:
Both IGF-I mRNA and IGF-II mRNA level expressed in the periodontal tissues were increased by orthodontic activation during various stages of the estrous cycle. But a similar pattern emerged that the IGF-I mRNA level was the lowest in the estrous stage, whereas its level was the highest in the proestrus stage (P < 0.05). No rhythm of IGF-II mRNA expression found during the estrous cycle.
Conclusion:
It was concluded that local mechanical stimulation directly enhanced the IGF expression. In contrast to the IGF-II, IGF-I was also influenced by the sex hormone rhythm during the estrous cycle.
