Related Experiment Videos
Serum insulin-like growth factor-I (IGF-I), IGF-binding protein-3, and growth hormone levels in collodion babies: a
Selim Kurtoglu1, Mehmet Adnan Ozturk, Esad Koklu
1Department of Paediatrics, Division of Neonatology and Paediatric Endocrinology & Metabolism, School ofMedicine, Erciyes University, Kayseri, Turkey. selimk@erciyes.edu.tr
Insights
Collodion babies exhibit lower insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) levels, alongside elevated growth hormone (GH) levels, compared to controls. Further research is needed to understand the mechanisms behind these hormonal differences in collodion infants.
Area of Science:
- Pediatric Endocrinology
- Neonatal Research
- Growth Hormone Axis
Background:
- Collodion babies often experience growth failure, indicating potential endocrine dysregulation.
- Hormonal imbalances, particularly involving growth hormone (GH), insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3), may contribute to poor growth in these infants.
Purpose of the Study:
- To investigate and compare serum levels of GH, IGF-I, and IGFBP-3 in collodion babies versus a control group.
- To explore the relationship between these growth factors and clinical parameters such as birth weight and gestational age in collodion infants.
Main Methods:
- A case-control study was conducted with 23 collodion babies (study group) and matched controls.
- Blood samples were collected within 2 hours of birth for serum GH, IGF-I, and IGFBP-3 measurements.
- Controls were matched for gestational age (±7 days) and birth weight (±100 g).
Main Results:
- Collodion babies demonstrated significantly lower serum IGF-I and IGFBP-3 levels compared to controls.
- Serum GH levels were found to be higher in collodion babies than in the control group.
- Birth weight was positively correlated with IGF-I and IGFBP-3, and negatively correlated with GH levels.
Conclusions:
- Collodion infants present with distinct alterations in the GH/IGF-I axis, characterized by reduced IGF-I and IGFBP-3 and elevated GH.
- These findings suggest a potential role for endocrine factors in the growth disturbances observed in collodion babies.
- The underlying mechanisms driving these hormonal differences require further investigation.
Aim:
Because growth failure occurs in many collodion babies, we investigated serum growth hormone (GH), insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) levels in collodion babies admitted to Gevher Nesibe Hospital, Kayseri, Turkey between 1999 and 2006.
Patients And Method:
The newborns diagnosed clinically as 'collodion baby' were included in the study group (group 1). Because collodion babies are usually born small for gestational age (SGA) and/or premature, a control group (group 2) was formed by selecting the first infant admitted immediately after each study infant who matched for gestational age (+/- 7 days) and birth weight (+/- 100 g). All infants' blood samples were collected within the first 2 h of life for measurements of serum GH, IGFBP-3 and IGF-I levels.
Results:
Group 1 consisted of 23 collodion babies (13 males and 10 females) with gestational ages ranging from 32 to 42 weeks, and birth weights ranging from 1,300 to 3,600 g. Ten were born premature and 16 were SGA. Serum IGF-I and IGFBP-3 levels were lower but serum GH levels were higher in collodion babies than in controls. Birth weight was positively correlated with serum IGF-I (r = 0.310, p = 0.046) and IGFBP-3 (r = 0.389, p = 0.011) levels. Serum GH level was negatively correlated with birth weight (r = -0.376, p = 0.014), serum IGF-I (r = -0.567, p <0.001) and IGFBP-3 (r = -0.444, p = 0.003).
Conclusion:
Collodion babies had lower serum IGF-I and IGFBP-3 levels but higher serum GH levels than controls in the present case-control study. The underlying mechanism needs to be explored.
