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Cardiac troponins and left ventricular hypertrophy in hemodialysis patients

Dejan Petrović1, Radmila Obrenović, Biljana Stojimirović

  • 1Clinic of Urology and Nephrology, Department of Haemodialysis, Clinical Centre "Kragujevac", Kragujevac, Serbia. aca96@Eunet.yu

Clinical Laboratory
|September 11, 2008
PubMed

Insights

Elevated cardiac troponins (cTnT, cTnI) correlate with left ventricular (LV) hypertrophy in hemodialysis patients. Higher troponin levels indicate significantly lower survival rates over one year.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Medicine

Background:

  • Cardiovascular diseases are a primary cause of mortality in hemodialysis patients.
  • Left ventricular (LV) hypertrophy is a key predictor of adverse cardiovascular outcomes in this population.
  • Cardiac troponins (cTnT, cTnI) serve as biomarkers for myocardial injury.

Purpose of the Study:

  • To determine the prevalence of LV hypertrophy and elevated serum cardiac troponins (cTnT, cTnI) in hemodialysis patients.
  • To investigate the correlation between serum cardiac troponin levels and LV hypertrophy.
  • To assess the impact of cardiac troponins on one-year survival rates in hemodialysis patients.

Main Methods:

  • A study involving 115 hemodialysis patients (mean age 53.3 years).
  • Measurements included serum cTnT, cTnI, and echocardiographic parameters of LV hypertrophy (LVPWd, IVSd, iLVEDV, LVMi).
  • Statistical analysis was used to identify correlations and survival differences.

Main Results:

  • Significant positive correlations were observed between serum troponin T and LV hypertrophy indicators (IVSd, LVPWd, iLVEDV, LVMi).
  • Patients with elevated cardiac troponin T (>0.10 ng/ml) and troponin I (>0.15 ng/ml) exhibited significantly lower one-year survival rates.
  • These findings highlight the prognostic value of cardiac troponins in this cohort.

Conclusions:

  • Serum troponin T concentration is significantly correlated with echocardiographic measures of LV hypertrophy in hemodialysis patients.
  • Elevated serum cardiac troponin levels are associated with reduced one-year survival in hemodialysis patients.
  • Cardiac troponins are valuable biomarkers for risk stratification in hemodialysis patients with cardiovascular disease.
Abstract

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