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Published on: September 10, 2014
Gene expression profiling of skeletal muscle in exercise-trained and sedentary rats with inborn high and low VO2max
Anja Bye1, Morten A Høydal, Daniele Catalucci
1Department of Circulation and Medical Imaging, Norwegian University of Science and Technology NTNU, Trondheim, Norway.
Abstract:
The relationship between inborn maximal oxygen uptake (VO(2max)) and skeletal muscle gene expression is unknown. Since low VO(2max) is a strong predictor of cardiovascular mortality, genes related to low VO(2max) might also be involved in cardiovascular disease. To establish the relationship between inborn VO(2max) and gene expression, we performed microarray analysis of the soleus muscle of rats artificially selected for high- and low running capacity (HCR and LCR, respectively). In LCR, a low VO(2max) was accompanied by aggregation of cardiovascular risk factors similar to the metabolic syndrome. Although sedentary HCR were able to maintain a 120% higher running speed at VO(2max) than sedentary LCR, only three transcripts were differentially expressed (FDR
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