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Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
Published on: January 22, 2015
Modified chitosans for oral drug delivery
Martin Werle1, Hirofumi Takeuchi, Andreas Bernkop-Schnürch
1Department of Drug Delivery Technology and Science, Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 5-6-1 Mitahora-Higashi, Gifu 502-8585, Japan.
Journal of Pharmaceutical Sciences
|September 11, 2008
Summary
Chemically modified chitosans show promise for oral drug delivery, enhancing the transport of peptides, proteins, genes, and other substances. This review details novel chitosan derivatives, their properties, and synthesis methods.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Pharmaceutical Sciences
Background:
- Chitosan, a cationic polysaccharide, is widely researched for oral drug delivery applications.
- Recent advancements focus on chemically modified chitosans to enhance their oral delivery capabilities.
- Novel derivatives include trimethyl-chitosans, thiolated chitosans, and PEGylated chitosans.
Purpose of the Study:
- To review various modified chitosan derivatives for oral drug delivery.
- To discuss the properties and synthesis of these novel chitosan polymers.
- To highlight their expanding applications beyond peptides and proteins.
Main Methods:
- Literature review of chemically modified chitosan derivatives.
- Analysis of synthesis routes for novel chitosan polymers.
- Evaluation of properties and applications in drug delivery.
Main Results:
- Chemically modified chitosans exhibit improved properties for oral drug delivery.
- These derivatives are effective for delivering peptides, proteins, genes, and efflux pump substrates.
- A range of novel chitosan derivatives have been developed and characterized.
Conclusions:
- Modified chitosans represent a significant advancement in oral drug delivery systems.
- Their versatility extends to the delivery of diverse therapeutic agents.
- Further research into their synthesis and application is warranted.
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