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Ethnic differences in warfarin maintenance dose requirement and its relationship with genetics

Hedi Schelleman1, Nita A Limdi, Stephen E Kimmel

  • 1Center for Clinical Epidemiology and Biostatistics, and Department of Biostatistics & Epidemiology, University of Pennsylvania School of Medicine, 826 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA. hschelle@mail.med.upenn.edu

Pharmacogenomics
|September 11, 2008
PubMed
Summary

Warfarin dosing varies significantly between individuals, influenced by genetic factors like CYP2C9 and VKORC1 alleles. Understanding this genetic diversity is crucial for optimizing warfarin therapy across different populations.

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