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Localization, Identification, and Excision of Murine Adipose Depots
Published on: December 4, 2014
Adipose tissue: the link between obesity and cardiovascular disease
Vanessa DeClercq1, Carla Taylor, Peter Zahradka
1Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada.
Abstract:
The ever-increasing prevalence of cardiovascular disease (CVD) associated with obesity is linked through signaling pathways within adipose tissue. Adipose tissue functions as an endocrine organ, producing and secreting a variety of bioactive molecules. In obesity, the adipose tissue itself undergoes changes in cell size which alters its normal physiological function. Altered adipocyte function changes production and secretion of adipokines, such as leptin, adiponectin, angiotensinogen, plasminogen activator inhibitor-1, resistin, and several inflammatory molecules. Adipokines interact with other tissues and cells in the body, including many pathways linked to CVD. Future research in the area of obesity-related CVD requires further investigation into a combination of lifestyle and pharmacological therapies that alter adipokine production by reducing adipocyte size.
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