Similarities between pre-eclampsia and atherosclerosis: a protective effect of physical exercise?

Area of Science:

• Obstetrics and Gynecology
• Cardiovascular Disease Research
• Reproductive Health

Background:

• Pre-eclampsia (PE) is a major cause of maternal and fetal mortality.
• PE shares pathophysiological similarities with atherosclerosis, including oxidative stress and endothelial dysfunction.
• Physical exercise is known to protect against cardiovascular events, but its role in PE prevention is less understood.

Purpose of the Study:

• To describe the similarities between atherosclerosis and pre-eclampsia.
• To review existing studies on the impact of physical activity on PE risk.
• To discuss potential mechanisms for physical activity as a PE prophylactic approach.

Main Methods:

• Literature review of studies evaluating physical activity and PE risk.
• Comparative analysis of pathogenic mechanisms in atherosclerosis and PE.
• Discussion of potential prophylactic mechanisms of physical activity.

Main Results:

• Pre-eclampsia and atherosclerosis share common risk factors, lesions, and involve oxidative stress and endothelial dysfunction.
• Few studies have investigated the impact of physical activity on reducing PE risk.
• Physical activity may offer a protective effect against PE, similar to its cardiovascular benefits.

Conclusions:

• Physical activity is a potential prophylactic strategy for pre-eclampsia.
• Further research is needed to elucidate the mechanisms and confirm the efficacy of exercise in PE prevention.
• Understanding the links between PE and cardiovascular disease can inform preventative strategies.