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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
Published on: January 28, 2014
Candidate circulating biomarkers for the cardiovascular disease continuum
Olena Dotsenko1, Julia Chackathayil, Jeetesh V Patel
1Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, England.
Current Pharmaceutical Design
|September 11, 2008
Summary
Identifying new cardiac biomarkers is crucial for predicting cardiovascular events. This review covers promising plasma biomarkers like C-reactive protein and natriuretic peptides for improved risk stratification.
Area of Science:
- Cardiovascular Medicine
- Biomarker Research
- Atherothrombosis
Background:
- Traditional risk factors inadequately explain cardiovascular disease predisposition and treatment responses.
- Early identification and risk stratification of cardiovascular outcomes are research priorities.
- There is a need for novel biomarkers in atherothrombotic disease management.
Purpose of the Study:
- To review biomarker qualification principles for clinical practice.
- To provide an overview of targeted biomarker development in cardiovascular disease.
- To discuss promising plasma biomarkers for clinical risk assessment.
Main Methods:
- Review of epidemiological and clinical studies.
- Analysis of evidence for candidate plasma biomarkers.
- Discussion of biomarker qualification and clinical implementation.
Main Results:
- C-reactive protein, coagulation/inflammatory mediators, and natriuretic peptides show potential.
- These biomarkers can aid in risk stratification for cardiovascular events.
- Biomarker qualification principles guide clinical integration.
Conclusions:
- Novel plasma biomarkers are essential for enhancing cardiovascular risk assessment.
- Targeted biomarkers improve the stratification of individuals at risk.
- Further research supports the clinical utility of these biomarkers in atherothrombosis.
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