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Updated: Jul 1, 2026

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
Published on: April 6, 2022
Flavonoids: cellular and molecular mechanism of action in glucose homeostasis
Luisa Helena Cazarolli1, Leila Zanatta, Elga Heloisa Alberton
1Departamento de Bioquímica, Centro de Ciências Biológicas, Bairro Trindade, Cx, Postal 5069, CEP: 88040-970, Florianópolis, SC, Brazil.
Abstract:
The purpose of this review is to discuss the cellular and molecular mechanisms of action of flavonoids focusing on carbohydrate metabolism. The beneficial effects of flavonoids have been studied in relation to diabetes mellitus, either through their capacity to avoid glucose absorption or to improve glucose tolerance. Furthermore, flavonoids stimulate glucose uptake in peripheral tissues, regulate the activity and/or expression of the rate-limiting enzymes in the carbohydrate metabolism pathway and act per se as insulin secretagogues or insulin mimetics, probably, by influencing the pleiotropic mechanisms of insulin signaling, to ameliorate the diabetes status.
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